Harris has created several series dominated by Southern women who feel deep ambivalence towards their family, history, and community. In her delightfully light Aurora Teagarden series, the main character is a feisty librarian "Roe" who finds herself in the most untenable situations; bodies falling from the sky into her yard and the like.

The intriguing yet darker character of Lily Bard appears in the "Shakespeare's" series. Lily, the victim of a brutal rape and torture, has abandoned her connections with her life in Memphis, Tennessee and moved to the small town of Shakespeare, Arkansas. Determined to cut her self off mentally from the world, Lily focuses on martial arts and bodybuilding while cleaning the homes of specifically chosen clients. Although wanting to live on the fringes of society, Lily is continually drawn into the life of Shakespeare through foul play. As the series progresses her attachment to the quirky characters and eccentric lifestyle of the town only increases.

Her Southern Gothic Sookie Stackhouse series details the life of a mind reader located in a small southern town inhabited by members of the otherworld. Vampires, shape-shifters and all sorts of creatures inhabit the pages of this popular series.

The annotated manuscript of Living Dead in Dallas and the dump header for Club Dead are both from her Sookie Stackhouse series written 2002-2003.

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