Oxford Mississippi is located about eighty miles south of Memphis, Tennessee, on Highway 6 between Batesville and Tupelo. The closest airports providing commercial jet service are the Memphis International Airport and the Tupelo Regional Airport. The Oxford University Airport provides limited small aircraft service as well as private service. Amtrak provides service to Memphis via the “City of New Orleans” route. Regular bus service is available within the city of Oxford and on campus via the OUT Bus Service.

There are two Libraries. The J.D. Williams Library houses the main collection, Archives and Special Collections, and the AICPA Library. The Science Library is located within the Thad Cochran Research Center.